IGF-1 LR3 (Long Arginine 3) is a synthetic analog of human insulin-like growth factor-1 featuring an arginine substitution at position 3 and a 13-amino acid N-terminal extension. In research settings, it is investigated for its enhanced binding affinity to IGF-1 receptors, reduced interaction with IGF-binding proteins (IGFBPs), and prolonged half-life of 20-30 hours, making it a subject of interest in studies on PI3K-Akt signaling pathways, MAPK-ERK cascades, cellular proliferation, protein synthesis, and metabolic regulation.
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